| Arthur Bueno on Thu, 16 Sep 1999 18:54:17 +0200 |
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| Syndicate: XANAX PLACEBO |
Date: Thu, 16 Sep 1999 01:29:44 -0800
From: /m/e/t/a/ <meta@null.net>
Xanax Tablets contain alparzolam which is a triazolo analog of the
1,4-benzodiazepine class of central nervous system-active compounds.
The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo
[4,3-alpha][1,4]benzodiazepine.
Inactive ingredients: Cellulose, corn starch, docusate sodium, lactose,
magnesium strearate, silicon dioxide and sodium benzoate. In addition, the
0.5 mg tablet contains FD& C Yellow No. 6 and the 1 mg tablet contains FD&
C Blue No. 2.
09/13/99
DG DISPATCH - EFNS: Depression Commonly Misdiagnosed As Dementia
Early Treatment Improves HIV-Related Dementia
09/09/99
Attenade Effective In the Treatment Of ADD And ADHD
Communication Training, Drug Therapy Combination Greatly Reduces
Self-Injury
08/31/99
Alcohol Researchers Identify Medication That Lessens Relapse Risk
08/18/99
IPA MEETING: Aricept Effective In Long-Term Treatment Of Alzheimer's
08/17/99
IPA CONGRESS: Aricept Effective, Well-Tolerated For Long-Term
Alzheimer's Treatment
08/10/99
PSYCHIATRY CONGRESS: Seroquel Effective Treatment For Schizophrenia
In Partial Responders
08/06/99
PSYCHIATRY CONGRESS: Paxil Effective Treatment For Social Anxiety
Disorder
08/03/99
Boys Treated With Stimulants Less Likely To Abuse Drugs As Adults
08/02/99
Chronic, Heavy Cocaine Use Associated With Long-Lasting Impaired
Function
ISP CONGRESS: Zyprexa Reduces Hyperprolactinemia Prevalence In
Schizophrenia Patients
07/12/99
Neurontin Reduces Symptoms Of Social Phobia
Discontinuation-Emergent Symptom Incidence
Percentage of 641 Xanax-Treated Panic Disorder Patients
Reporting Events
Body System/Event
Neurologic Gastrointestinal
Insomnia 29.5 Nausea/Vomiting 16.5
Lightheadedness 19.3 Diarrhea 13.6
Abnormal involuntary Decreased salivation 10.6
movement 17.3
Headache 17.0 Metabolic-Nutritional
Muscular twitching 6.9 Weight loss 13.3
Impaired Coordination 6.6 Decreased appetite 12.8
Muscle tone disorders 5.9
Weakness 5.8 Dermatological
Psychiatric Sweating 14.4
Anxiety 19.2
Fatigue and Tiredness 18.4 Cardiovascular
Irritability 10.5 Tachycardia 12.2
Cognitive disorder 10.3
Memory impairment 5.5 Special Senses
Depression 5.1 Blurred vision 10.0
Confusional state 5.0
07/05/99
Clozapine May Restore Information Processing To Schizophrenia Patients
06/29/99
Depression In Breast Cancer Patients Linked To Lack Of Estrogen
For Heart Disease Patients, Depression Takes Heavy Toll
Once-Daily Adderall As Effective As Twice Daily For ADHD
06/25/99
DG DISPATCH - HEADACHE: Sumatriptan Non-Responders Often Have Other
Personality Disorders
06/21/99
ADA MEETING: Diabetes and Depression Enhance Each Other's Severity
and Cost
06/18/99
Zyprexa Reduces Symptoms Of Mania, Severe Depression In Bipolar Disorder
06/17/99
BIPOLAR DISORDERS MEETING: Researchers Find New Approach To Treating
Bipolar Disorder
DG DISPATCH - ENDO 99: Anorexia Nervosa Linked To Serious Bone Loss
Youth Stress Key Predictor Of Later Hypertension
06/02/99
Neotrofin Effective In Alzheimer's Disease Treatment
05/28/99
DG DISPATCH - APA MEETING: Cognitive Improvement Associated With
Olanzapine
05/27/99
DG DISPATCH - APA MEETING: Combination Treatment Often Necessary For
Bipolar Disorder
DG DISPATCH - APA MEETING: HIV Infection Associated With Psychiatric
Symptoms
DG DISPATCH - APA MEETING: Overview Of Treatment For Bipolar Disorder
05/25/99
AGS MEETING: ProMem Improves Symptoms Of Alzheimer's
Low Cholesterol Levels May Be Linked To Depression, Anxiety
Smoking And Depression Weakens Immune System
05/21/99
APA MEETING: Seroquel Improves Psychotic Symptoms Of Alzheimer's,
Parkinson's Diseases
Anxiety Disorders
Incidence of
Intervention
Treatment-Emergent Because of
Symptom Incidence(1) Symptom
XANAX PLACEBO XANAX
Number of Patients 565 505 565
% of Patients Reporting:
CENTRAL NERVOUS SYSTME
Drowsiness 41.0 21.6 15.1
Lightheadedness 20.8 19.3 1.2
Depression 13.9 18.1 2.4
Headache 12.9 19.6 1.1
Confusion 9.9 10.0 0.9
Insomnia 8.9 18.4 1.3
Nervousness 4.1 10.3 1.1
Syncope 3.1 4.0 *
Dizziness 1.8 0.8 2.5
Akathisia 1.6 1.2 *
Tiredness/Sleepiness * * 1.8
GASTOINTESTINAL
Dry Mouth 14.7 13.3 0.7
Constipation 10.4 11.4 0.9
Diarrhea 10.1 10.3 1.2
Nausea/Vomiting 9.6 12.8 1.7
Increased Salivation 4.2 2.4 *
CARDIOVASCULAR
Tachycardia/Palpitations 7.7 15.6 0.4
Hypotension 4.7 2.2 *
SENSORY
Blurred Vision 6.2 6.2 0.4
MUSCULOSKELETAL
Rigidity 4.2 5.3 *
Tremor 4.0 8.8 0.4
CUTANEOUS
Dermatitis/Allergy 3.8 3.1 0.6
OTHER
Nasal Congestion 7.3 9.3 *
Weight Gain 2.7 2.7 *
Weight Loss 2.3 3.0 *
Notes: * None reported
(1) Events reported by 1% or more of Xanax patients
are included.
05/20/99
APA MEETING: Seroquel Appears To Work In Some Bipolar And
Schizoaffective Patients
05/19/99
APA MEETING: Effexor Produces Superior Remission Rates To SSRIs
APA MEETING: Effexor XR Produces Significant Relief From Depression
In First Week of Treatment
APA MEETING: Once-Daily Adderall More Effective Than Ritalin For ADHD
05/18/99
APA MEETING: Drug-Psychotherapy Combo Effective For Chronic Depression
APA MEETING: Early Response To Zoloft Indicative Of Future Success In
Panic Disorder Treatment
Prozac Tablet To Be Available In The U.S. June 1, 1999
Reboxetine Effective In Treating Depression Symptoms
05/17/99
APA MEETING: Electromagnetic Stimulation Shows Promise For
Treatment-Resistant Depression
APA MEETING: Zaleplon Effective Against Insomnia Without Residual
Effects
Greater Orgasm Dysfunction Found In Patients Taking Zoloft Than
Wellbutrin SR
05/14/99
SBP MEETING: Risperdal Significantly Decreases Schizophrenia Relapse
Risk
05/13/99
Researchers Look To Omega-3 Fatty Acid For Manic Depression Treatment
Study Shows Psychotherapy As Effective As Drug Therapy For Atypical
Depression
05/11/99
Adolescent Depression Often Continues To Adulthood
FDA Approves Paxil In The U.S. For Social Anxiety Disorder
05/06/99
Paxil Approved In Canada For Social Anxiety Disorder
05/03/99
Newest Depression Treatments Widely Prescribed For Children
04/30/99
Luvox Effective For Treating Social Phobia
04/28/99
AANS MEETING: Study Shows Depression In Brain Tumor Patients May Go
Untreated
04/26/99
DG DISPATCH - AAN: Autism Linked To Smaller Volumes In Hippocampus
And Amygdala
DG DISPATCH - AAN: Metifronate Improves Psychiatric Profile Of
Patients With Alzheimer's Disease
04/21/99
Risperdal Improves Learning Capacity, Skills Acquisition For
Schizophrenia Patients
04/20/99
DG Dispatch - AAN: Significant Differences Found In Male And Female
Brains
04/19/99
Ampalex Produces Cognition Improvement In Schizophrenia Patients
DG Dispatch - AAN: Differences In Brain Size Found In Hyperactive
Children
Panic Disorder
Treatment-Emergent
Symptom Incidence*
XANAX PLACEBO
Number of Patients 1388 1231
% of Patients Reporting:
CENTRAL NERVOUS SYSTEM
Drowsiness 76.8 42.7
Fatigue and Tiredness 48.6 42.3
Impaired Coordination 40.1 17.9
Irritability 33.1 30.1
Memory Impairment 33.1 22.1
Lightheadedness/Dizziness 29.8 36.9
Insomnia 29.4 41.8
Headache 29.2 35.6
Cognitive Disorder 28.8 20.5
Dysarthria 23.3 6.3
Anxiety 16.6 24.9
Abnormal Involuntary Movement 14.8 21.0
Decreased Libido 14.4 8.0
Depression 13.8 14.0
Confusional State 10.4 8.2
Muscular Twitching 7.9 11.8
Increased Libido 7.7 4.1
Change in Libido (Not Specified) 7.1 5.6
Weakness 7.1 8.4
Muscle Tone Disorders 6.3 7.5
Syncope 3.8 4.8
Akathisia 3.0 4.3
Agitation 2.9 2.6
Disinhibition 2.7 1.5
Paresthesia 2.4 3.2
Talkativeness 2.2 1.0
Vasomotor Disturbances 2.0 2.6
Derealization 1.9 1.2
Dream Abnormalities 1.8 1.5
Fear 1.4 1.0
Feeling Warm 1.3 0.5
GASTROINTESTINAL
Decreased Salivation 32.8 34.2
Constipation 26.2 15.4
Nausea/Vomiting 22.0 31.8
Diarrhea 20.6 22.8
Abdonimal Distress 18.3 21.5
Increased Salivation 5.6 4.4
CARDIO-RESPIRATORY
Nasal Congestion 17.4 16.5
Tachycardia 15.4 26.8
Chest Pain 10.6 18.1
Hyperventilation 9.7 14.5
Upper Respiratory Infection 4.3 3.7
SENSORY
Blurred Vision 21.0 21.4
Tinnitus 6.6 10.4
MUSCULOSKELETAL
Muscular Cramps 2.4 2.4
Muscle Stiffness 2.2 3.3
CUTANEOUS
Sweating 15.1 23.5
Rash 10.8 8.1
OTHER
Increased Appetite 32.7 22.8
Decreased Appetite 27.8 24.1
Weight Gain 27.2 17.9
Weight Loss 22.6 16.5
Micturition Difficulties 12.2 8.6
Menstrual Disorders 10.4 8.7
Sexual Dysfunction 7.4 3.7
Edema 4.9 5.6
Incontinence 1.5 0.6
Infection 1.3 1.7
Note: * Events reported by 1% or more of Xanax patients are included.
04/08/99
Genetic, Familial Factors Influence ADHD
04/05/99
Adderall As Effective, Longer-Lasting Than Ritalin For ADHD
03/26/99
ADAA MEETING: Effexor XR Effective In Treating Symptoms Of
Generalised Anxiety Disorder
03/24/99
SSRI Antidepressants Effective In Young Patients With Body Dysmorphic
Disorder
03/23/99
ACS MEETING: Improved Ritalin Offers Smaller Doses And Fewer Side
Effects
SGO MEETING: Women With Ovarian Cancer Have Higher Rates Of
Depression, Anxiety
03/22/99
Social Support May Extend Life Of People With Schizophrenia
Treating Depression, Anxiety, Alcohol Abuse Significantly Reduces
Teen Suicide Risk
Vision Problems, Not Confusion, Cause Alzheimer's Patients To Become
Lost
03/18/99
Newer Antidepressant Drugs As Effective As Older-Generation Treatments
03/16/99
AAGP MEETING: Seroquel Effective At Treating Psychosis In Patients
With Alzheimer's, Parkinson's
Cognitive-Behaviour Therapy And Drug Treatments Effective In Treating
Late-Life Insomnia
03/12/99
Effexor XR Approved In The U.S. For Anxiety
XANAX PLACEBO
Low High Low High
Hematology
Hematocrit * * * *
Hemoglobin * * * *
Total WBC Count 1.4 2.3 1.0 2.0
Neutrophic Count 2.3 3.0 4.2 1.7
Lymphocyte Count 5.5 7.4 5.4 9.5
Monocyte Count 5.3 2.8 6.4 *
Eosinophil Count 3.2 9.5 3.3 7.2
Basophil Count * * * *
Urinalysis
Albumin - * - *
Sugar - * - *
RBD/HPF - 3.4 - 5.0
WBC/HPF - 25.7 - 25.9
Blood Chemistry
Creatinine 2.2 1.9 3.5 1.0
Bilirubin * 1.6 * *
SGOT * 3.2 1.0 1.8
Alkaline Phosphatase * 1.7 * 1.8
Note: * Less than 1%
03/10/99
Epilepsy Drug Lamictal Appears Effective For Bipolar Depression
03/08/99
Viagra Not A Cure For All Sexual Problems, Researchers Says
03/05/99
Depression Linked To Reduced Blood Pressure Control
Exelon Effective For Mild To Moderate Alzheimer's
03/04/99
Memantine Effective For Patients With Severe Dementia
03/01/99
Continued Treatment With Prozac Reduces Panic Attack Frequency
02/15/99
Lower Serotonin Levels Linked To Relapses In Bulimia Nervosa
Most Patients With Obsessive-Compulsive Disorder Improve After
Several Decades
02/11/99
Adding Natural Hormone Boosts Brain Function In Hypothyroidism
02/10/99
Celexa Approved In Canada For Treatment Of Depression
02/05/99
No Relationship Between Dental Amalgam And Alzheimer's Disease
01/29/99
Depression Linked To Higher Death Risk
Women At Greater Risk Of Depression After Heart Attack
01/08/99
Frequent Digestion Complaints May Point To Psychiatric Disorders
Research Shows No Link Between Mononucleosis And Depression
01/05/99
Psychotherapy And Nortriptyline Effective For Recurrent Depression In
Elderly
01/04/99
Risk Of Schizophrenia Onset Linked To Brain Abnormalities
12/16/98
ACN MEETING: Seroquel More Effective Than Risperidone In Minimising EPS
ACN MEETING: Seroquel Shown To Be Effective For Alzheimer's, Parkinson's
12/15/98
ACN MEETING: Zyprexa Reduces Behavioural, Psychiatric Symptoms
Related To Alzheimer's
Behavioural Therapy Effective In Treating Urinary Incontinence
Risperdal Reduces Dementia And Other Psychoses In Elderly Patients
XANAX Tablets are available as follows:
0.25 mg (white, oval, scored)
Bottles of 100 NDC 0009-0029-01
Reverse Numbered Unit Dose (100) NDC 0009-0029-46
Bottles of 500 NDC 0009-0029-02
Bottles of 1000 NDC 0009-0029-14
0.5 mg (peach, oval, scored)
Bottles of 100 NDC 0009-0055-01
Reverse Numbered Unit Doses (100) NDC 0009-0055-46
Bottles of 500 NDC 0009-0055-03
Bottles of 1000 NDC 0009-0055-15
1 mg (blue, oval, scored)
Bottles of 100 NDC 0009-0090-01
Reverse Numbered Unit Dose (100) NDC 0009-0090-46
Bottles of 500 NDC 0009-0090-04
Bottles of 1000 NDC 0009-0090-13
2 mg (white, oblong, multi-scored)
Bottles of 100 NDC 0009-0094-01
Bottles of 500 NDC 0009-0094-03
12/11/98
One-Third Of Children In Road Traffic Accidents Develop Stress Disorder
12/04/98
Researchers Find New Indicators For Alzheimer's Disease
11/24/98
Five Top Warning Signals Of Depression Identified
Sertraline Found Safe And Effective For Obsessive-Compulsive Disorder
In Children
Tacrine Slows Cognitive Deterioration For Alzheimer's Patients
11/23/98
Childhood Loss Linked To Later Health Problems
11/17/98
Sertraline Beneficial For Ongoing Treatment Of Chronic Depression
11/16/98
Study Shows Prozac Can Reduce Symptoms Of Panic Disorder
11/10/98
Chronic Stress Puts Heart Disease Patients At Greater Risk
11/03/98
Remeron More Effective, Faster Working Than Cipramil or Paxil, Study
Shows
10/30/98
Evidence Of Brain Injury In Ecstasy Users
Olanzapine More Tolerable, As Effective As Clozaril For
Treatment-Resistant Patients
10/29/98
Serious Crime Victims Risk PTSD, Multiple Disorders
10/28/98
Treatment of Depression May Help Reduce Mortality In Older Women
10/22/98
Older Adults' Speech-Processing Difficulties May Stem From Fast,
Noisy Talk, Not Deafness
Prenatal Cocaine Exposure Leads To Lower IQ Scores, Language Skills
10/20/98
Elevated Homocysteine Levels May Be Possible Risk Factor For
Alzheimer Disease
10/19/98
FDA Approves Versed Syrup For Pediatric Pre-Operative Sedation
10/15/98
Altered Brain Chemistry In Bulimia Nervosa Patients Persists After
Recovery
10/08/98
Seroxat/Paxil Approved In UK For Social Anxiety Disorder
"From morning till evening and on through the night we are floating upon
processes and systems that we don't understand."
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